Silvia Angeloni Suter
078 682 32 34
SiMPLInext radically extends the reliability, scope and quality of data acquired using in-vitro models of biological barriers by toxicologists and drug designers, without impacting processes or protocols.
Permeable cell culture inserts coupled with progress in epithelial tissue engineering in the 80s enabled in-vitro testing of both toxicity and drug delivery. The porous plastic material currently used to support cells, a 10μm thick plastic membrane, limits such studies to soluble chemicals and effectively precludes kinetic studies. Furthermore, affects the quality, reliability and reproducibility of experiments.
By replacing this plastic membrane with a 20x thinner ceramic one perforated in a periodic pattern, SiMPLI extends essential industry standard in-vitro testing protocols to all types of substances (non soluble molecules, aggregates, nanoparticles, …). Three scientific publications using intestinal, BBB and lung tissue models demonstrate the straightforward pathway to unlock in-vitro relevance.
Leveraging micro fabrication tools SiMPLInext further enables the inclusion of sensors and MEMs in contact with cells for the continuous monitoring of their metabolism, confluence and health. This monitoring in turns guarantees quality and relevance of the data acquired.
This advanced and innovative technology is packaged in a very familiar well plate insert format virtually eliminating the learning curve while leveraging the breath of existing protocols and tools. This why it is called CoMPLI.
SiMPLInext aims to develop a full suite of continuously monitoring/exposure modules designed to accompany cell cultures from inoculation to death. SiMPLInext’s objective is to commoditize any sufficiently mature technology by integrating it into a module and provide it in combination with other modules as opposed to the current approach which requires specialized experiments.
SiMPLInext will do for in-vitro cultures what smartphones have done to telephone, radio, GPS, heart rate monitor, guide book, computer, …
Marchés visés :Advanced Cell Based assays, Preniclinical screening, Drug discovery
Mots-clés : Biological barriers, in vitro models, preclinical screening, toxicology, drug designer, innovation and ergonomincs, 3Rs